以下是關於DHEA較新的一些研究報告( Sorry 指整理到2006年的一些文獻,實際上還有很多paper)
(1): ANDROGEN MODULATION OF HIPPOCAMPAL SY+NAPTIC PLASTICITY:
….. DHEA 可增強腦部海馬迴神經生長及反應,增進認知功能,並改善
心情狀況 ……. Neuroscience 138 (2006) 957-965
(2): Circulating Steroid Hormones and the Risk of Prostate Cancer:
….. 血中DHEA-S濃度較高之人所患Prostate Cancer(攝護腺癌)之侵
犯危險性較低 ……. Cancer Epidemiol Biomarkers Prev 2006;15
(1). January 2006
(3): Clinical uses and misuses of dehydroepiandrosterone :
….. 研究證實補充DHEA對腎上腺功能不足,腦下垂體功能低下,骨質
疏鬆,全身性紅斑性狼瘡症,憂鬱症, 及精神分裂症的患者有正面
效果. ……. Current Opinion in Pharmacology 2003, 3:635-641
(4): Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis.
….. 研究證實血中 DHEA-S 濃度低下與發炎性關節炎有關,補充DHEA可有效改善發炎性關節炎等症狀. …… Arthritis Res
2001, 3:182-188
(5): Dehydroepiandrosterone Sulfate (DHEA-S) and Risk for Mortality Among Older
Taiwanese.
….. 研究顯示血中DHEA-S濃度較低的台灣老年人,三年內死亡率
較高 ……. 2006 Elsevier Inc.
(6): Mitotic and neurogenic effects of dehydroepiandrosterone(DHEA) on human
neural stem cell cultures derived from the fetal cortex
….. 研究顯示DHEA可維持並促進人類神經幹細胞生長
….. 3202-3207 / PNAS / March 2. 2004 / Vol. 101/No. 9
(7): Dehydroepiandrosterone Supplementation Improves Endothelial Function and
Insulin Sensitivity in Men
….. 補充DHEA改善血管內皮細胞功能,增加胰島素利用率,進而降
低心血管疾病 …… The Journal of Clinical Endocrinology &
Metabolism 88(7):3190-3195:2003
(8): G protein-associated,specific membrane binding sites mediate the neuroprotective
effect of dehydroepiandrosterone
….. 神經細胞以特有的G蛋白質與DHEA結合,進而啟動一連串的
神經保護機制 …… The FASEB Journal January 11,2006
(9): Dehydroepiandrosterone attenuates allergic airway inflammation in Dermato-
phagoides farinae-sensitized mice.
….. 研究證實補充DHEA可降低血清中 IL4, IL%, INF-r濃度,並抑制
過敏性呼吸道發炎反應 ……. J Microbiol Immunol Infect
2002;35:199-202
(10):Double-Blind Treatment of Major Depression With Dehydroepiandrosterone
….. 研究顯示補充DHEA對重度憂鬱症的病人具有顯著效果
…… Am J Psychiatry 156:4, April 1999
(11):Long-term low-dose dehydroepiandrosterone oral supplementation in early and
late postmenopausal women modulates endocrine parameters and synthesis of
neuroactive steroids
….. 停經後婦女長期補充DHEA可增進女性及男性荷爾蒙,減少更年
期症狀,及增加腦部Neurosteroids和Endophin,為有效之補充品
…. FERTILITY AND STERILITY VOL. 80 NO. 6. DECEMBER 2003
(12):Metabolic effects of dehydroepiandrosterone replacement therapy in post-
menopausal women
….. 長期補充DHEA可改善Insulin使用率,增加HDL且降低LDL及
TG, 有效改善更年期婦女的代謝指數
….. European Journal of Endocrinology (2001) 145: 457-461
(13):Dehydroepiandrosterone(DHEA),DHEA sulfate,and aging: Contribution of the
DHEAge STUDYto a sociobiomedical issue
….. 補充DHEA改善骨質,減低Osteoclast活性,顯著增加性慾,改善膚
質: 包括含水性,上皮厚度,皮脂及斑點產生之改善,使用一年(每
天50mg) 可改善老化現象而且證實無副作用
….. PNAS / April 11, 2000 / vol. 97 / No. 8 / 4279-4284
(14):Dehydroepiandrosterone REPLACEMENT IN WOMEN WITH
ADRENAL INSUFFICIENCY
….. 對腎上腺功能不足的婦女補充DHEA可顯著降低膽固醇,改善憂
鬱及焦慮症狀,增進對房事的興趣及滿意度
….. The New England Journal of Medicine Volume 341 Number 14 1013
(15): Dehydroepiandrosterone inhibits the progression phase of mammary carcino-
genesis by inducing cellular senescence via a p16-dependent but p53-indepen-
dent mechanism
….. DHEA可增強p16和p21的表現,促進乳癌細胞老化及凋亡,進而抑
制乳癌的生成 …… Breast Cancer Research2005,7:R1132-R1140
(16):Effect of DHEA on Abdominal Fat and Insulin Action in Elderly Women & Men
….. 補充DHEA可顯著減少腹部及皮下脂肪達13cm2,並增加Insulin的
使用率,可用來預防及治療與腹部肥胖有關的代謝症狀
…… JAMA, November 10. 2004 Vol 292,No 18 ,2243
(17):Rapid column-switching liquid chromatography/mass spectrometric assay for
DHEA-sulfate in the plasma of patients with Alzheimer’s disease
….. Alzheimer’s disease(阿茲海默氏症)(早老化性老年癡呆症)病患其血中
DHEA-S濃度較一般人低下,證實DHEA-S濃度乃是瞭解阿茲海默氏
症病因的重要指標 …… BIOMEDICAL CHROMATOGRAPHY
(18):Neurosteroids and cholinergic systems: implications for sleep and cognitive pro-
cesses and potential role of age-related changes
….. 腦內DHEA-S濃度與老年退化性睡眠及記憶障礙有關
….. Psychopharmacology DOI 10.1007/s00213-005-0254-6
(19):Neurosteroids in depression: a review
….. 在憂鬱症患者補充DHEA可增進sigmal神經傳導,增加認知功能,有
效改善憂鬱狀況
….. Psychopharmacology(2003) 165:97-110 DOI 10.1007/s00213-002-
1257-1
(20): Neurosteroid Quantification in Human Brain Regions: Comparison between Al-
zheimer’s and Nondemented Patients
…... 腦內DHEA-S濃度降低常形成Plaques 及neurofibrillary tangles而
造成老年癡呆症
….. The Journal of Clinical Endocrinology & Metabolism 87(11):5138-5143
(21):Salivary cortisol, dehydroepiandrosterone-sulfate(DHEA-S) and testosterone in
womwn with chronic migraine
….. 慢性偏頭痛患者DHEA-S濃度較低而Cortisol濃度較高,證實腎上腺
功能改變造成慢性偏頭痛患者在代謝及心理的病症
….. J Headache Pain (2006) DOI 10.1007/s10194-006-0274-6
(22):Dehydroepiandrosterone Treatment of Women With Mild-to-Moderate Systemic
Lupus Erythematosus
….. 研究證實以DHEA治療SLE病人的可行性, 可顯著減少SLE發作次
數,並增進病人整體之活動力
….. ARTHRITIS & RHEUMATISM Vol. 46, No. 11. November 2002,pp
2924-2927
(23):Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response
in human umbilical vein endothelial cells
….. DHEA可抑制與發炎反應有關的分子表現,因此可用來治療類似Atherosclerosis(動脈粥狀硬化)等慢性發炎疾病
….. ATHEROSCLEROSIS
(24):Dehydroepiandrosterone inhibits the EXPRESSION OF CARCINOGEN-ACTIVATING ENZYMES IN VIVO
….. DHEA可調控肝癌活化酵素的活性,可作為重要的預防性化療補充品
….. Int. J. Cancer: 105,321-325 (2003)
(25): Dehydroepiandrosterone Replacement Administration::Pharmacokinetic and Pharmacodynamic Studies in Healthy Elderly Subjects
….. 老年人每天補充DHEA 25/50mg證實是安全的
….. The Journal oh Clinical Endocrinology & Metabolism
以下是關於DHEA較新的一些研究報告
(1): ANDROGEN MODULATION OF HIPPOCAMPAL SYNAPTIC PLASTICITY:
….. DHEA 可增強腦部海馬迴神經生長及反應,增進認知功能,並改善
心情狀況 ……. Neuroscience 138 (2006) 957-965
(2): Circulating Steroid Hormones and the Risk of Prostate Cancer:
….. 血中DHEA-S濃度較高之人所患Prostate Cancer(攝護腺癌)之侵
犯危險性較低 ……. Cancer Epidemiol Biomarkers Prev 2006;15
(1). January 2006
(3): Clinical uses and misuses of dehydroepiandrosterone :
….. 研究證實補充DHEA對腎上腺功能不足,腦下垂體功能低下,骨質
&nbs |
